Target Health Blog

January

Earworms

January 29, 2018

,Quiz

Orphan Drug Development at Target Health Inc.

January 30, 2017

,News

Target Health is very pleased that it has prepared, submitted and obtained over 20 orphan drug designations, with 3 of these products reaching the market. There were 2 additional orphan programs in which Target Health played a major role.

Thrilling Rescue Revealed, of U.S. Medics & Nurses, During WW 2 in Albania

January 30, 2017

,History of Medicine

Harold Hayes was a member of a band of airborne American medics and nurses who crash-landed in Nazi-occupied Albania in 1943 and trekked 600 miles to their rescue. All of these brave heroes were military trained army lieutenants. Harold Hayes, was the last surviving member of a band of airborne American medics and nurses who crashed-landed in Nazi-occupied Albania in 1943 and survived German attacks, blizzards and horrific privations on a 600-mile trek to their rescue on the Adriatic coast. He died last Sunday in Medford, Ore. He was 94. His death, at a hospital, followed an operation to remove a blood clot from his leg, his daughter Margaret Bleakley said.

Disparities in Cancer Mortality Among US Counties, 1980-2014

January 30, 2017

,Public Health

Cancer is a leading cause of morbidity and mortality in the United States which results in a high economic burden. As a result, a study published in the Journal of the American Medical Association (2017;317(4):388-406), was performed to estimate age-standardized mortality rates by US county from 29 cancers.

The Cancer Genome Atlas (TCGA) Research Network Study Identifies Genomic Features of Cervical Cancer

January 30, 2017

,Oncology

Cervical cancer accounts for more than 500,000 new cases of cancer and more than 250,000 deaths each year worldwide. According to NIH, the vast majority of cases of cervical cancer are caused by persistent infection with oncogenic types of HPV, and that effective preventive vaccines against the most oncogenic forms of HPV have been available for a number of years, with vaccination having the long-term potential to reduce the number of cases of cervical cancer.

Elevated Levels of Belladonna in Certain Homeopathic Teething Products

January 30, 2017

,Regulatory

Homeopathic teething products have not been evaluated or approved by the FDA for safety or effectiveness. The agency is unaware of any proven health benefit of the products, which are labeled to relieve teething symptoms in children. In September 2016, the FDA warned against the use of these products after receiving adverse event reports.

The Rooster Asian New Year Celebration

January 30, 2017

,Target Healthy Eating

An online ad for Korean vodka, intrigued me, especially when there was no way to buy it in the U.S. After some research, it turned out two countries stocked it: Korea and Germany. Executive Director of Target Health Inc., Yong Joong Kim was contacted for advice. Luckily, for the newsletter, Y.J. Kim’s wife was heading to Korea for a visit.

Transmission of Extensively Drug-Resistant Tuberculosis in South Africa

January 23, 2017

,News

Drug-resistant tuberculosis threatens recent gains in the treatment of tuberculosis and human immunodeficiency virus (HIV) infection worldwide.

Birth Control

January 23, 2017

,Quiz

Birth control has been used since ancient times, but effective and safe methods of birth control only became available in the 20th century. Planning, making available, and using birth control is called family planning.

Ancient Methods of Birth Control

January 23, 2017

,History of Medicine

The Egyptian Ebers Papyrus from 1550 BCE and the Kahun Papyrus from 1850 BCE have within them some of the earliest documented descriptions of birth control: the use of honey, acacia leaves and lint to be placed in the vagina to block sperm.

Warm Curry Cauliflower Salad with Avocado-Cilantro-Lime Dressing

January 23, 2017

,Target Healthy Eating

It’s not every day that we rave about a salad; however, this warm curry creation is worth trying. It’s extremely easy to make, so no time wasted. Marinating overnight, does a lot of the work for you.

FDA Approves Trulance for Chronic Idiopathic Constipation

January 23, 2017

,Regulatory

According to the National Institutes of Health, an estimated 42 million people are affected by constipation. Chronic Idiopathic Constipation (CIC) is a diagnosis given to those who experience persistent constipation and for whom there is no structural or biochemical explanation.

Gene Complex Linked To Premenstrual Mood Disorder

January 23, 2017

,Women's Health

By the late 1990s, investigators at the NIMH demonstrated that women who regularly experience mood disorder symptoms just prior to their periods were abnormally sensitive to normal changes in sex hormones, even though their hormone levels were normal. But the cause remained a mystery.

Scientists Provide First Eevidence That Carbamates Can Upset Circadian Rhythms

January 20, 2017

,News

Synthetic chemicals commonly found in insecticides and garden products bind to the receptors that govern our biological clocks researchers have found.

Ongoing and Completed eSource Programs at Target Health and ICH E6(R2)

January 20, 2017

,News

Target e*CTR® (eClinical Trial Record) is Target Health’s patented eSource solution fully integrated with Target e*CRF®. A de novo 510(k) was cleared in December 2015 that used direct data entry at the time of the office visit, and an NDA was submitted to FDA with 7 studies which all used Target e*CTR. There were no FDA inspection findings in any of these programs.

First Humans Arrived In North America A Lot Earlier Than Believed

January 17, 2017

,News

The timing of the first entry of humans into North America across the Bering Strait has now been set back 10,000 years, scientists report.

The Paperless Clinical Trial – New Publication in Applied Clinical Trials

January 16, 2017

,News

On 4 January 2017, Applied Clinical Trials published an online paper, entitled, “Regulatory Considerations when Designing and Running 21st Century Paperless Clinical Trials.“ The paper is coauthored by Jonathan Helfgott, MS, former the Associate Director for Risk Science at FDA CDER OSI and the main author of FDA’s eSource Guidance, and Jules Mitchel, MBA, PhD, President, Target Health Inc. Jonathan is currently the Coordinator of the Regulatory Science Graduate Program at Johns Hopkins University.

Azithromycin

January 16, 2017

,Quiz

Azithromycin is an antibiotic indicated for the treatment of a number of bacterial infections.

100 Years Later, Death Theories of Healer, Grigori Rasputin Remain a Mystery

January 16, 2017

,History of Medicine

Grigori Yefimovich Rasputin was a Russian peasant, an experienced traveler, a mystical faith healer, and trusted friend of the family of Nicholas II, the last Tsar of the Russian Empire. He became an influential figure in Saint Petersburg, especially after August 1915 when Nicholas took command of the army fighting in World War I.

Blood Biomarker May Predict Recovery From Concussions

January 16, 2017

,Neurology

Athletes who return to play before full recovery from concussions are at high risk for long-term symptoms like headaches, dizziness, and cognitive deficits with subsequent concussions. About half of college athletes see their post-concussive symptoms resolve within 10 days, but in others, the symptoms become chronic.

Parental Obesity Linked to Delays in Child Development

January 16, 2017

,Pediatrics

Research indicates that about 1 in 5 pregnant women in the United States is overweight or obese.

New NCI Drug Formulary Will Expedite Use of Agents In Clinical Trials

January 16, 2017

,Regulatory

The National Cancer Institute (NCI) has launched a new drug formulary (the “NCI Formulary”) that will enable investigators at NCI-designated Cancer Centers to have quicker access to approved and investigational agents for use in preclinical studies and cancer clinical trials. The NCI Formulary could ultimately translate into speeding the availability of more-effective treatment options to patients with cancer.

Brain Impairments In Premature Infants May Begin In The Womb

January 10, 2017

,News

Even before they are born, premature babies may display alterations in the circuitry of their developing brains, according to a first-of-its kind research study.

Cultural Differences May Leave Their Mark On DNA

January 10, 2017

,News

A UC San Francisco-led study has identified signatures of ethnicity in the genome that appear to reflect an ethnic group’s shared culture and environment, rather than their common genetic ancestry.

Dave Luke, PharmD, FACA, FCCP, Joins Target Health As Sr. Director of Clinical And Scientific Affairs

January 9, 2017

,News

As part of the continuing growth of Target Health Inc. we welcome Dave Luke, PharmD, FACA, FCCP, as Sr. Director of Clinical and Scientific Affairs. Dave will work closely with all departments at Target Health to provide both clinical, scientific and leadership support for all of our programs.

Homosexuality

January 9, 2017

,History of Medicine

The earliest Western documents (in the form of literary works, art objects, and mythographic materials) concerning same-gender relationships are derived from ancient Greece.

Hearing Loss Prevalence Declining in Adults Aged 20-69

January 9, 2017

,Public Health

According to an article published in JAMA Otolaryngology – Head & Neck Surgery, (15 December 2016), hearing loss among U.S. adults aged 20 to 69 has declined over the last decade, even as the number of older Americans continues to grow. These findings, also confirm that hearing loss is strongly associated with age and other demographic factors such as gender, race/ethnicity, and education. Noise exposure, which is potentially preventable, was also significant but less strongly associated after adjustment for other factors..

Clinical Trial Demonstrates Shrinkage in Pediatric Neural Tumors

January 9, 2017

,Oncology

Neurofibromatosis type 1 (NF1), also called von Recklinghausen’s disease, is a rare genetic disorder characterized by the development of multiple noncancerous (benign) tumors of nerves and skin (neurofibromas) and areas of abnormally decreased or increased coloration (hypo- or hyperpigmentation) of the skin. Areas of abnormal pigmentation typically include pale tan or light brown discolorations (cafe-au-lait spots) on the skin of the trunk and other regions as well as freckling, particularly under the arms (axillary) and in the groin (inguinal) area.

FDA Approves First Drug For Spinal Muscular Atrophy

January 9, 2017

,Regulatory

Spinal muscular atrophy (SMA), is a hereditary disease that causes weakness and muscle wasting because of the loss of lower motor neurons controlling movement. There is wide variability in age of onset, symptoms and rate of progression.