Target Health Blog

Neurology

Outcomes After Diagnosis Of Mild Cognitive Impairment in a Large Autopsy Series

May 8, 2017

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Neurology

A study recently reported the Annals of Neurology (2017;81:549-559), was performed to determine clinical and neuropathological outcomes following a clinical diagnosis of mild cognitive impairment (MCI). For the study, data were drawn from a large autopsy series (N=1,337) of individuals followed longitudinally from normal or MCI status to death, derived from 4 Alzheimer Disease (AD) Centers in the United States.

Human Forebrain Circuits Under Construction

May 1, 2017

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Neurology

During mid-to-late gestation, neurons migrate from deep brain structures to their appointed places and organize themselves into the key working tissue of what will become the human cortex, the outer layer of the brain and seat of higher-order mental functions. This building process is complex and especially vulnerable to genetic and environmental insults that can set the stage for autism, schizophrenia, and other neurodevelopmental brain disorders.

Gene Silencing Shows Promise for Treating 2 Fatal Neurological Disorders

April 17, 2017

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Neurology

In 1996, it was discovered that mutations in the ataxin 2 gene cause spinocerebellar ataxia type 2 (SCA2), a fatal inherited disorder that primarily damages a part of the brain called the cerebellum, causing patients to have problems with balance, coordination, walking and eye movements.

Urinary Biomarker That May Help Track ALS

April 3, 2017

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Neurology

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which motor neurons, cells that control muscle activity such as walking, talking and breathing, gradually die off, resulting in paralysis. There is no cure for ALS.

Blood-based NfL: A Biomarker for Differential Diagnosis of Parkinsonian Disorder

March 13, 2017

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Neurology

In order t0 improve the diagnostic workup of parkinsonian disorders, a study published online in Neurology (2017; 88:930-937), was performed to determine if blood neurofilament light chain (NfL) protein can discriminate between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally high diagnostic accuracy as CSF NfL.

Stem Cell Transplants May Induce Long-Term Remission of Multiple Sclerosis

February 6, 2017

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Neurology

Multiple sclerosis (MS), is an autoimmune disease in which the immune system attacks the central nervous system. MS symptoms vary widely and may include motor and speech difficulties, weakness, fatigue and chronic pain. The most common form of MS is relapsing-remitting MS, which is characterized by periods of mild or no symptoms interspersed with symptom flare-ups or relapses. Over years, the disease can worsen and shift to a progressive form.

Blood Biomarker May Predict Recovery From Concussions

January 16, 2017

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Neurology

Athletes who return to play before full recovery from concussions are at high risk for long-term symptoms like headaches, dizziness, and cognitive deficits with subsequent concussions. About half of college athletes see their post-concussive symptoms resolve within 10 days, but in others, the symptoms become chronic.

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