Target Health Blog

Disrupting the Gut Microbiome May Affect Some Immune Responses to Flu Vaccination

September 9, 2019

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Immunology
Source:

The normal human gut microbiome is a flourishing community of microorganisms, some of which can affect the human immune system. According to a paper published in Cell (5 September 2019), a study found that oral antibiotics, which can kill gut microorganisms, can alter the human immune response to seasonal influenza vaccination.

For the study, the authors examined 33 healthy adult participants. One group of 22 volunteers was studied during the 2014-2015 flu season, and the second group with 11 volunteers was studied during the 2015-2016 flu season. The group of 22 volunteers had high pre-existing immunity to the influenza virus strains contained in the 2014-2015 seasonal influenza vaccine. The group of 11 volunteers had low immunity to the 2015-2016 seasonal influenza vaccine's virus strains.

All study participants received a seasonal influenza vaccine. Half the participants in each group also received a five-day oral course of a broad-spectrum antibiotic regimen (consisting of neomycin, vancomycin, and metronidazole) before receiving the vaccine. By analyzing stool and blood serum samples taken at various times up to one year after vaccination, the authors tracked the participants' immune response to the influenza vaccines, as well as the diversity and abundance of the organisms in their gut microbiomes.

As expected, most participants who received antibiotics experienced reduced levels of gut bacteria. In addition, among the 2015-2016 participants who had little prior immunity to the seasonal influenza virus vaccine strains, a course of antibiotics hindered their immune responses to one of the three influenza virus strains in the vaccine, an H1N1 A/California-specific virus. According to the authors, this likely indicated that should they have been exposed to this H1N1 virus after vaccination, these participants would be less protected against infection with that strain than people who had not received antibiotics. This finding supports earlier research results in mice.

The authors also found that people who took antibiotics experienced changes to their immune systems that promoted a pro-inflammatory state, similar to a condition seen in older adults who have received influenza vaccines. The authors hypothesized that this pro-inflammatory state is related to the process by which the microbiome regulates the metabolism of bile acid-with fewer microorganisms, this process is disrupted. Humans' microbiomes change naturally as they age, and the researchers suggest that further research on these pathways could provide insights into why older adults respond differently to influenza vaccination and why they have weaker immune systems overall.

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