Global, internet-based clinical trials (G-IBCTs) can offer convenient, cost-effective solutions for the streamlining aspects of the clinical research process.
The rationale for the use of an internet-based clinical trial to obtain safety, pharmacokinetic and pharmacodynamic data in dose escalation study in neonates, with hyperbilirubinemia, who need exchange transfusion.
Global, internet-based clinical trials (G-IBCTs) can offer convenient, cost-effective solutions for the streamlining aspects of the clinical research process.
Dermatology provides an unmet need for drug development. There are two reasons to develop drugs for topical use. The first is to treat skin diseases and disorders such as psoriasis, acne, actinic keratosis, cancer, eczema, etc. These conditions represent some of the most common and chronic disease states in man. The second reason is to deliver systemically active drugs through the skin to enhance drug activity by, 1. avoiding first pass metabolism, 2. reducing toxicity and 3. improving compliance.
The present study was designed to determine the effects of oral administration of the nitric oxide-precursor Larginine, in combination with the alpha2 blocker yohimbine, on subjective and physiological (vaginal photoplethysmography) responses to erotic stimuli in postmenopausal women with Female Sexual Arousal Disorder (FSAD).
This paper reviews laboratory and clinical data concerning oral phentolamine mesylate, Vasomax, an alpha-1, alpha-2 adrenergic receptor antagonist developed specifically for treatment of erectile dysfunction.
