Dermatology provides an unmet need for drug development. There are two reasons to develop drugs for topical use. The first is to treat skin diseases and disorders such as psoriasis, acne, actinic keratosis, cancer, eczema, etc. These conditions represent some of the most common and chronic disease states in man. The second reason is to deliver systemically active drugs through the skin to enhance drug activity by, 1. avoiding first pass metabolism, 2. reducing toxicity and 3. improving compliance.